ISCE 2019

This year's ISCE conference will be held at April 10-14, 2019 in Florida.

I have been invited for a poster presentation, entitled Determination of ventricular excitation propagation in abnormal heart beats using a moving dipole model.

In this presentation, I will use published simulated ventricular excitation processes with given action potentials (AP) on a course heart model, as well as body surface potentials, determined by forward-calculation of the heart's APs onto 163 electrode positions (see EDGAR database).

In a first step, the time course of the global heart vector during excitation is calculated as the spatial integral over the (spatial) gradient of the AP distribution. In a second step, the body surface potentials are used for adjusting the moving dipole model. The moving dipole analysis approach may be considered as validated if the moving dipole time courses from step 2 are comparable to the time courses of the global heart vector from step 1.

Below are links (will open in a new window) to 3-dimensional representations of the excitation process of several simulated extopic ventricular beats.
(The simulations files are in the order of 30MB, so that loading may take some time.)
The display can be rotaded with the left mouse, and zoomed with the right mouse button. Please use the lower buttons for hiding/showing the thorax and the heart, and for scrolling through the excitation time course (2 ms steps).
The red lines indicate the local AP gradients, i.e. the local dipoles. The violet needle indicates the global heart vector.
Scrolling to the very end of the time slider will display the complete time course of the global heart vector.

  • Simulation_10_RVANTERIOR
    Excitation starting in the anterior wall of the right ventricle.
  • Simulation_09_RVPOSTERIOR
    Excitation starting in the posterior wall of the right ventricle.
  • Simulation_07_LVANTERIOR
    Excitation starting in the basal section of the anterior wall of the left ventricle.
  • Simulation_05_LVAPEX
    Excitation starting in the apical section of anterior wall of the left ventricle.

  • Happy simulation!